PERSPECTIVE Molecular Simulation of Protein Aggregation
نویسندگان
چکیده
Computer simulation offers unique possibilities for investigating molecular-level phenomena difficult to probe experimentally. Drawing from a wealth of studies concerning protein folding, computational studies of protein aggregation are emerging. These studies have been successful in capturing aspects of aggregation known from experiment and are being used to refine experimental methods aimed at abating aggregation. Here we review molecular-simulation studies of protein aggregation conducted in our laboratory. Specific attention is devoted to issues with implications for biotechnology. Biotechnol. Bioeng. 2007;96: 1–8. 2006 Wiley Periodicals, Inc.
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تاریخ انتشار 2006